hrp0086p2-p57 | Adrenal P2 | ESPE2016

False-Positive Increases of Steroid Hormone Precursors Mimicking 11β-Hydroxylase-Deficiency in a Preterm Infant

Welters Alena , Roschinger Wulf , Franzel Julia , Sabir Hemmen , Mayatepek Ertan , Meissner Thomas , Kummer Sebastian

Background: In premature and small-for-date infants, immature adrenal enzyme activity, adrenal stress responses and impaired hepatic clearance may lead to mild to moderate false-positive increases of steroid hormone precursors. This complicates screening programs for congenital adrenal hyperplasia (CAH) in these patients.Objective and hypotheses: We present a preterm female infant (born at 33 weeks of gestation) who’s newborn screening 55 h after bi...